{"id":15942,"date":"2020-01-10T06:00:28","date_gmt":"2020-01-10T06:00:28","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=15942"},"modified":"2020-01-11T10:08:25","modified_gmt":"2020-01-11T10:08:25","slug":"kelch13-protein-responsible-for-artemisinin-resistance","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/","title":{"rendered":"Kelch13 Protein Responsible for Artemisinin Resistance"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>A mechanism of resistance to artemisinin is identified and researchers find that breastfeeding could help to prevent malaria in babies.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-15942-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-0-8\/42625645-44100-2-24b0dc17ace75.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-0-8\/42625645-44100-2-24b0dc17ace75.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-0-8\/42625645-44100-2-24b0dc17ace75.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>A mechanism of resistance to artemisinin in malaria parasites has been identified. The antimalarial drug is activated by haemoglobin degradation products, which are generated in part by a protein called Kelch13. A mutated or inactivated form of this protein inhibits the degradation process by reducing haemoglobin endocytosis. The inability for haemoglobin to enter cells means that the artemisinin cannot be activated, reducing its ability to clear the malaria parasites.<\/p><p>And breastfeeding could help to prevent malaria in babies. Researchers collected samples of breast milk in Northern Uganda and showed for the first time that 15% of breast milk from mothers with asymptomatic malaria contain key antigens, either <em>Plasmodium falciparum<\/em> histidine-rich protein 2 or lactate dehydrogenase. Future work will evaluate whether proteins obtained this way play a role in infant immunity.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1126\/science.aax4735\" target=\"_blank\" rel=\"noopener noreferrer\">A Kelch13-Defined Endocytosis Pathway Mediates Artemisinin Resistance in Malaria Parasites<\/a><\/p><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1001\/jamapediatrics.2019.5209\" target=\"_blank\" rel=\"noopener noreferrer\">Malaria Antigen Shedding in the Breast Milk of Mothers From a Region With Endemic Malaria<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits: <\/strong>Kelch13 location and interactome (<a href=\"https:\/\/science.sciencemag.org\/content\/367\/6473\/51\/tab-figures-data\" target=\"_blank\" rel=\"noopener noreferrer\">Science<\/a>)<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>","protected":false},"excerpt":{"rendered":"<p>A mechanism of resistance to artemisinin is identified and researchers find that breastfeeding could help to prevent malaria in babies.<\/p>\n","protected":false},"author":1,"featured_media":15943,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog\" \/>\n<meta property=\"og:description\" content=\"A mechanism of resistance to artemisinin is identified and researchers find that breastfeeding could help to prevent malaria in babies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"The Fight Malaria Blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-01-10T06:00:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-01-11T10:08:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/01\/Kelch13-Protein-Responsible-for-Artemisinin-Resistance_lc9qv1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Thomas Locke\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Thomas Locke\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\"},\"author\":{\"name\":\"Thomas Locke\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a\"},\"headline\":\"Kelch13 Protein Responsible for Artemisinin Resistance\",\"datePublished\":\"2020-01-10T06:00:28+00:00\",\"dateModified\":\"2020-01-11T10:08:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\"},\"wordCount\":230,\"publisher\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\"},\"articleSection\":[\"Malaria Minute\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\",\"url\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\",\"name\":\"Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog\",\"isPartOf\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#website\"},\"datePublished\":\"2020-01-10T06:00:28+00:00\",\"dateModified\":\"2020-01-11T10:08:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/fight-malaria-blog.local\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kelch13 Protein Responsible for Artemisinin Resistance\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#website\",\"url\":\"https:\/\/fight-malaria-blog.local\/\",\"name\":\"The Fight Malaria Blog\",\"description\":\"Malaria News, Views and Interviews.\",\"publisher\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fight-malaria-blog.local\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\",\"name\":\"Fight Malaria\",\"url\":\"https:\/\/fight-malaria-blog.local\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg\",\"contentUrl\":\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg\",\"caption\":\"Fight Malaria\"},\"image\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a\",\"name\":\"Thomas Locke\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g\",\"caption\":\"Thomas Locke\"},\"url\":\"https:\/\/fight-malaria-blog.local\/author\/fightmalaria\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/","og_locale":"en_GB","og_type":"article","og_title":"Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog","og_description":"A mechanism of resistance to artemisinin is identified and researchers find that breastfeeding could help to prevent malaria in babies.","og_url":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/","og_site_name":"The Fight Malaria Blog","article_published_time":"2020-01-10T06:00:28+00:00","article_modified_time":"2020-01-11T10:08:25+00:00","og_image":[{"width":800,"height":500,"url":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/01\/Kelch13-Protein-Responsible-for-Artemisinin-Resistance_lc9qv1.png","type":"image\/png"}],"author":"Thomas Locke","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Thomas Locke","Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#article","isPartOf":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/"},"author":{"name":"Thomas Locke","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a"},"headline":"Kelch13 Protein Responsible for Artemisinin Resistance","datePublished":"2020-01-10T06:00:28+00:00","dateModified":"2020-01-11T10:08:25+00:00","mainEntityOfPage":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/"},"wordCount":230,"publisher":{"@id":"https:\/\/fight-malaria-blog.local\/#organization"},"articleSection":["Malaria Minute"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/","url":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/","name":"Kelch13 Protein Responsible for Artemisinin Resistance - The Fight Malaria Blog","isPartOf":{"@id":"https:\/\/fight-malaria-blog.local\/#website"},"datePublished":"2020-01-10T06:00:28+00:00","dateModified":"2020-01-11T10:08:25+00:00","breadcrumb":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/kelch13-protein-responsible-for-artemisinin-resistance\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/fight-malaria-blog.local\/"},{"@type":"ListItem","position":2,"name":"Kelch13 Protein Responsible for Artemisinin Resistance"}]},{"@type":"WebSite","@id":"https:\/\/fight-malaria-blog.local\/#website","url":"https:\/\/fight-malaria-blog.local\/","name":"The Fight Malaria Blog","description":"Malaria News, Views and Interviews.","publisher":{"@id":"https:\/\/fight-malaria-blog.local\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fight-malaria-blog.local\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/fight-malaria-blog.local\/#organization","name":"Fight Malaria","url":"https:\/\/fight-malaria-blog.local\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/","url":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg","contentUrl":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg","caption":"Fight Malaria"},"image":{"@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a","name":"Thomas Locke","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g","caption":"Thomas Locke"},"url":"https:\/\/fight-malaria-blog.local\/author\/fightmalaria\/"}]}},"_links":{"self":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts\/15942"}],"collection":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/comments?post=15942"}],"version-history":[{"count":0,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts\/15942\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/media\/15943"}],"wp:attachment":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/media?parent=15942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/categories?post=15942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/tags?post=15942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}