{"id":16214,"date":"2020-02-21T06:00:47","date_gmt":"2020-02-21T06:00:47","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16214"},"modified":"2020-02-20T17:04:18","modified_gmt":"2020-02-20T17:04:18","slug":"condensin-proteins-essential-for-malaria-proliferation-and-transmission","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/condensin-proteins-essential-for-malaria-proliferation-and-transmission\/","title":{"rendered":"Condensin Proteins Essential for Malaria Proliferation and Transmission"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>Scientists identify two proteins that are essential for the malaria parasite\u2019s genetic malleability, and the substance responsible for \u2018rosette\u2019 formation in human red blood cells is identified.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16214-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-1-20\/51379218-44100-2-a0e6cf3448009.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-1-20\/51379218-44100-2-a0e6cf3448009.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-1-20\/51379218-44100-2-a0e6cf3448009.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>Scientists have found that two proteins, called SMC2 and SMC4, mediate unusual cell division in the malaria parasite. It&#8217;s this atypical cell division that lends the parasite its genetic malleability, which helps it to survive under strain. The proteins are part of the condensin family, which are large protein complexes that play a critical role in chromosomic assembly and segregation in meiosis and mitosis. A better understanding of the parasite&#8217;s plasticity &#8211; and the mechanism of these proteins &#8211; could potentially unlock new therapies for the disease.<\/p><p>And one of the ways that the malaria parasite protects itself in the bloodstream is to attach itself to a non-infected red blood cell, forming what&#8217;s known as a rosette, leaving it undetected by the immune system. New research has indicated that this phenomenon is caused by a substance called IGFBP7, which is used in humans to regulate insulin.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2020.01.033\" target=\"_blank\" rel=\"noopener noreferrer\">Plasmodium Condensin Core Subunits SMC2\/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission<\/a><\/p><p><a href=\"https:\/\/doi.org\/10.7554\/eLife.51546\" target=\"_blank\" rel=\"noopener noreferrer\">Plasmodium-Infected Erythrocytes Induce Secretion of IGFBP7 to Form Type II Rosettes and Escape Phagocytosis <\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits: <\/strong><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:CondensinI%26II.png\" target=\"_blank\" rel=\"noopener noreferrer\">Wikimedia Commons<\/a><!-- wp:paragraph --><\/p>","protected":false},"excerpt":{"rendered":"<p>Scientists identify two proteins that are essential for the malaria parasite\u2019s genetic malleability, and the substance responsible for \u2018rosette\u2019 formation in human red blood cells is identified.<\/p>\n","protected":false},"author":1,"featured_media":16216,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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