{"id":16239,"date":"2020-03-20T06:00:42","date_gmt":"2020-03-20T06:00:42","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16239"},"modified":"2020-03-20T11:26:04","modified_gmt":"2020-03-20T11:26:04","slug":"pimms43-enables-malaria-parasite-to-evade-mosquito-immune-system","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/pimms43-enables-malaria-parasite-to-evade-mosquito-immune-system\/","title":{"rendered":"PIMMS43 Enables Malaria Parasite to Evade Mosquito Immune System"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>A protein called PIMMS43 enables the malaria parasite to evade the mosquito\u2019s immune system and scientists describe a highly conserved protein\u00a0in the malaria parasite\u00a0that is essential for the invasion of red blood cells.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16239-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-2-19\/57488611-44100-2-7fb2044a7a2d5.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-2-19\/57488611-44100-2-7fb2044a7a2d5.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-2-19\/57488611-44100-2-7fb2044a7a2d5.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>Scientists have found that a protein called PIMMS43 enables the malaria parasite to evade the mosquito\u2019s immune system.\u00a0 It allows for the development of oocysts, in which sporozoites are formed. Sporozoites are the form of the parasite that are injected into the human during a blood meal; targeting their formation in the mosquito could, therefore, prevent onward transmission. Neutralising PIMMS43 \u2013 either by eliminating it from the parasite genome or by preincubating the parasite with relevant antibodies \u2013 inhibits parasite development in the mosquito by allowing the mosquito\u2019s immune response to take hold. Interventions that target PIMMS43 could support existing vector control measures, as resistance to insecticides grows.\u00a0<\/p><p>And scientists have described a highly conserved protein in the malaria parasite that is essential for the invasion of red blood cells. The protein is associated with the rhoptry, and when knocked down, secretion of rhoptry antigens that coordinate red blood cell invasion is inhibited.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1073\/pnas.1919709117\" target=\"_blank\" rel=\"noopener noreferrer\">PIMMS43 Is Required for Malaria Parasite Immune Evasion and Sporogonic Development in the Mosquito Vector<\/a><\/p><p><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-15127-w\" target=\"_blank\" rel=\"noopener noreferrer\">PfCERLI1 Is a Conserved Rhoptry Associated Protein Essential for <em>Plasmodium Falciparum<\/em> Merozoite Invasion of Erythrocytes<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits:\u00a0<\/strong>Imperial College London [<a href=\"https:\/\/www.pnas.org\/content\/early\/2020\/03\/11\/1919709117\/tab-figures-data\" target=\"_blank\" rel=\"noopener noreferrer\">PNAS<\/a>]<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>","protected":false},"excerpt":{"rendered":"<p>A protein called PIMMS43 enables the malaria parasite to evade the mosquito\u2019s immune system and scientists describe a highly conserved protein\u00a0in the malaria parasite\u00a0that is essential for the invasion of red blood cells.<\/p>\n","protected":false},"author":1,"featured_media":16240,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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