{"id":16344,"date":"2020-04-10T06:00:14","date_gmt":"2020-04-10T05:00:14","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16344"},"modified":"2020-04-10T20:32:19","modified_gmt":"2020-04-10T19:32:19","slug":"enhancing-fc-dependent-effector-functions-could-improve-protective-efficacy-of-rtss","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/enhancing-fc-dependent-effector-functions-could-improve-protective-efficacy-of-rtss\/","title":{"rendered":"Enhancing Fc-Dependent Effector Functions Could Improve Protective Efficacy of RTS,S"},"content":{"rendered":"
The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\n

Enhancing antibody induction may improve the protective efficacy of RTS,S and researchers find that more gametocytes are produced when human infection is initiated by blood-stage parasites compared to mosquito bite.<\/p>\n\n

Malaria Minute on iTunes<\/a> and Spotify<\/a><\/p>\n

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Transcript:<\/strong><\/h5>\n

The RTS,S malaria vaccinate works by targeting the circumsporozoite protein, the major surface protein on the sporozoite, which is the form of the parasite that\u2019s injected into the human during a mosquito blood meal. A new study, published this week, has revealed more about how RTS,S provides protection against malaria. Researchers found that people with high levels of the vaccine-induced antibodies that mediate an Fc-dependent effector immune response against the parasite were more likely to be protected from malaria. Enhancing the induction of these antibodies may, therefore, help improve the protective efficacy of RTS,S.<\/p>\n

And researchers have found that more gametocytes are produced in controlled human malaria infection studies when the infection is initiated by blood-stage parasites compared to mosquito bite. This finding paves the way for a new model that will enable scientists to easily evaluate how effectively drugs and vaccines can block transmission.<\/p>\n

Sources:<\/strong><\/h5>\n

Multi-Functional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase I\/IIa Trial <\/a><\/p>\n

A Randomized Clinical Trial to Compare P. Falciparum<\/em> Gametocytaemia and Infectivity Following Blood-Stage or Mosquito Bite Induced Controlled Malaria Infection<\/a><\/p>\n

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Image Credits: <\/strong>US Army Africa [Flickr<\/a>]<\/p>\n\n\n<\/p>

Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>\n","protected":false},"excerpt":{"rendered":"

Enhancing antibody induction may improve the protective efficacy of RTS,S and researchers find that more gametocytes are produced when human infection is initiated by blood-stage parasites compared to mosquito bite.<\/p>\n","protected":false},"author":1,"featured_media":16346,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"\nEnhancing Fc-Dependent Effector Functions Could Improve Protective Efficacy of RTS,S - The Fight Malaria Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/enhancing-fc-dependent-effector-functions-could-improve-protective-efficacy-of-rtss\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enhancing Fc-Dependent Effector Functions Could Improve Protective Efficacy of RTS,S - 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