{"id":16417,"date":"2020-04-24T06:00:32","date_gmt":"2020-04-24T05:00:32","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16417"},"modified":"2020-04-22T20:16:59","modified_gmt":"2020-04-22T19:16:59","slug":"gene-drive-outcomes-not-determined-by-genetic-variation","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/gene-drive-outcomes-not-determined-by-genetic-variation\/","title":{"rendered":"Gene Drive Outcomes Not Determined by Genetic Variation"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>Genetic variation would seem to have little impact on the outcome of gene drive interventions due to conserved Cas9 target sites in populations of\u00a0<em>Anopheles\u00a0<\/em>mosquitoes.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16417-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-3-22\/66736092-44100-2-d575ad90e20f7.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-3-22\/66736092-44100-2-d575ad90e20f7.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-3-22\/66736092-44100-2-d575ad90e20f7.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>Gene drives are a system of genetic modification that use \u2018molecular scissors\u2019 to edit DNA sequences that self-perpetuate to ensure the rapid spread of mutation in a population. They offer new avenues for eradicating vector-borne diseases like malaria. They rely on the Cas9 system which works by recognising a specific 23-base pair stretch of DNA, assisted by a complementary RNA molecule which guides the enzyme and a donor DNA fragment that replaces the original DNA sequence. If there was genetic variation in the mosquito with respect to the RNA guide molecule used, however, it\u2019s thought that such recognition would be less likely, meaning that the gene drive could fail. But a new study published this week suggests that this isn\u2019t the case. Out of over 1,000 <em>Anopheles<\/em> mosquitoes analysed, around 90% had at least one target site for the Cas9 protein, suggesting that gene drives are still viable and not dependent on variation.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1038\/s41467-020-15204-0\" target=\"_blank\" rel=\"noopener noreferrer\">Abundance of Conserved CRISPR-Cas9 Target Sites Within the Highly Polymorphic Genomes of <em>Anopheles<\/em> and <em>Aedes<\/em> Mosquitoes<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits: <\/strong>CDC\/ James Gathany [<a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=18761\" target=\"_blank\" rel=\"noopener noreferrer\">18761<\/a>]<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Elena G\u00f3mez-D\u00edaz, Institute of Parasitology and Biomedicine, Spain<\/p>","protected":false},"excerpt":{"rendered":"<p>Genetic variation would seem to have little impact on the success of gene drive interventions due to conserved Cas9 target sites in populations of\u00a0Anopheles\u00a0mosquitoes.<\/p>\n","protected":false},"author":1,"featured_media":16418,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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