{"id":16525,"date":"2020-05-29T06:00:44","date_gmt":"2020-05-29T05:00:44","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16525"},"modified":"2020-05-29T12:23:00","modified_gmt":"2020-05-29T11:23:00","slug":"spleen-plays-major-role-in-plasmodium-vivax-infection","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/spleen-plays-major-role-in-plasmodium-vivax-infection\/","title":{"rendered":"Spleen Plays Major Role in Plasmodium vivax Infection"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>The spleen plays a major role in the expression of <em>P. vivax<\/em> genes and the production of antigens associated with clinical protection, and scientists develop an AI that can detect <em>Plasmodium<\/em> infection in the blood.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16525-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-4-28\/77435128-44100-2-3a269ca2a5533.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-4-28\/77435128-44100-2-3a269ca2a5533.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-4-28\/77435128-44100-2-3a269ca2a5533.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>Researchers have found that the spleen plays a major role in the expression of <em>Plasmodium vivax<\/em> genes that are responsible for cytoadhesion, a process that escalates malaria infection. The identified spleen-dependant antigens were immunogenic in natural infections and provoked an immune response associated with clinical protection. This suggests that the spleen plays a major role in <em>vivax<\/em> infection, not only in the expression of proteins for cytoadherence but in that it may also produce antigens associated with clinical protection.<\/p><p>And scientists have developed a piece of Artificial Intelligence that can detect <em>Plasmodium<\/em> infection in the blood. The deep learning technology classifies <em>Plasmodium falciparum<\/em> infection in blood sample images with over 99% accuracy. The AI was made available through a mobile app and a website, allowing for both on and offline diagnoses. The technology has not yet been tested with other forms of <em>Plasmodium<\/em> infection; it\u2019s unclear whether it can differentiate between them.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1073\/pnas.1920596117\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Plasmodium vivax<\/em> Spleen-Dependent Genes Encode Antigens Associated With Cytoadhesion and Clinical Protection<\/a><\/p><p><a href=\"https:\/\/doi.org\/10.3390\/diagnostics10050329\" target=\"_blank\" rel=\"noopener noreferrer\">Deep Learning Based Automatic Malaria Parasite Detection from Blood Smear and Its Smartphone Based Application<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits:\u00a0<\/strong><a href=\"http:\/\/oac.med.jhmi.edu\/Pathology\/Idmicro\/Parasite\/037B_Full.html\" target=\"_blank\" rel=\"noopener noreferrer\">Johns Hopkins School of Medicine<\/a><!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>","protected":false},"excerpt":{"rendered":"<p>The spleen plays a major role in the expression of P. vivax genes and the production of antigens associated with clinical protection, and scientists develop an AI that can detect Plasmodium infection in the blood.<\/p>\n","protected":false},"author":1,"featured_media":16526,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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