{"id":16537,"date":"2020-06-05T06:00:21","date_gmt":"2020-06-05T05:00:21","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16537"},"modified":"2020-06-05T08:32:24","modified_gmt":"2020-06-05T07:32:24","slug":"novel-malaria-drug-artefenomel-assessed-against-plasmodium-vivax-infection","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/novel-malaria-drug-artefenomel-assessed-against-plasmodium-vivax-infection\/","title":{"rendered":"Novel Malaria Drug Artefenomel Assessed Against Plasmodium vivax Infection"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>Artefenomel is assessed against\u00a0<em>Plasmodium vivax<\/em>\u00a0infection in humans to determine the minimum effective dose required for parasite clearance and LSHTM launch a beta version of The Global Vector Hub.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16537-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-3\/79229629-44100-2-24a30bb9a438d.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-3\/79229629-44100-2-24a30bb9a438d.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-3\/79229629-44100-2-24a30bb9a438d.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>With resistance to antimalarial drugs on the rise, new therapies are needed to control the disease. Artefenomel, a novel antimalarial drug, was assessed against <em>P. vivax<\/em> infection in malaria-na\u00efve adults to determine the minimum effective dose required for parasite clearance. In the study, 8 malaria-na\u00efve adults were experimentally infected with <em>Plasmodium vivax<\/em> and, 10 days later, given a 200mg dose of artefenomel. The drug was well-tolerated and resulted in the rapid clearance of parasites. Recrudescence occurred 10-14 days later in 7\/8 participants which allowed the use of pharmacokinetic and pharmacodynamic modelling to determine the minimum effective dose of 300mg.<\/p><p>And a beta version of the Global Vector Hub was launched this week. The open-access platform, created by the London School of Hygiene and Tropical Medicine, brings together information and research on vector control, with a specific section on malaria.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1093\/infdis\/jiaa287\" target=\"_blank\" rel=\"noopener noreferrer\">Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage <em>Plasmodium vivax<\/em> Infection<\/a><\/p><p><a href=\"https:\/\/globalvectorhub.lshtm.ac.uk\/\" target=\"_blank\" rel=\"noopener noreferrer\">The Global Vector Hub by LSHTM<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits:\u00a0<\/strong>CDC\/ Dr. Mae Mellvin [<a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=18997\" target=\"_blank\" rel=\"noopener noreferrer\">18997<\/a>]<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p><hr \/><p><strong>NB: <\/strong>Katharine Collins, Scientific Advisor to Fight Malaria, is one of the authors of \u2018Antimalarial Activity of Artefenomel Against&#8230;<i>Plasmodium Vivax <\/i>Infection\u2019, a paper covered in this week\u2019s podcast.<\/p>","protected":false},"excerpt":{"rendered":"<p>Artefenomel is assessed against Plasmodium vivax infection in humans to determine the minimum effective dose required for parasite clearance and LSHTM launch a beta version of The Global Vector Hub.<\/p>\n","protected":false},"author":1,"featured_media":16538,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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