{"id":16555,"date":"2020-06-26T06:00:01","date_gmt":"2020-06-26T05:00:01","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16555"},"modified":"2020-06-24T23:31:48","modified_gmt":"2020-06-24T22:31:48","slug":"cdk5-controls-atypical-replication-of-plasmodium-parasite","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/cdk5-controls-atypical-replication-of-plasmodium-parasite\/","title":{"rendered":"CDK5 Controls Atypical Replication of Plasmodium Parasite"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>CDK5 regulates atypical cell division in gametogony and is essential for DNA replication, and researchers assess whether two experimental vaccines can be combined to create a multistage vaccine against malaria.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16555-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-24\/85015116-44100-2-3298e99b28c2f.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-24\/85015116-44100-2-3298e99b28c2f.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-5-24\/85015116-44100-2-3298e99b28c2f.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>The transition between stages of <em>Plasmodium<\/em> infection is triggered by variation in activity of cyclin-dependent kinases, CDKs. In <em>Plasmodium berghei<\/em>, mouse malaria, a specific kinase called CDK-related kinase 5 is a critical regulator of atypical cell division in gametogony; the process by which gametes are formed. The kinase was also shown to be essential for DNA replication, interacting with a cyclin called SOC to form a complex called CSC.<\/p><p>And researchers have assessed whether two experimental vaccines can be combined to create a multistage vaccine against <em>Plasmodium vivax<\/em>. One vaccine uses the PvCSP protein and the other the PvAMA-1 protein. Both vaccines were immunogenic when given alone, but when mixed together had minimal effect on the immune responses. Importantly, the combination vaccine provided partial protection against <em>Plasmodium berghei<\/em> sporozoites expressing the PvCSP protein.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.7554\/eLife.56474\" target=\"_blank\" rel=\"noopener noreferrer\">A Divergent Cyclin\/Cyclin-Dependent Kinase Complex Controls the Atypical Replication of a Malaria Parasite During Gametogony and Transmission<\/a><\/p><p><a href=\"https:\/\/doi.org\/10.3390\/microorganisms8060916\" target=\"_blank\" rel=\"noopener noreferrer\">A Multistage Formulation Based on Full-Length CSP and AMA-1 Ectodomain of Plasmodium vivax Induces High Antibody Titers and T-cells and Partially Protects Mice Challenged with a Transgenic <em>Plasmodium berghei<\/em> Parasite<\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits:\u00a0<\/strong>Paul Christian Burda [<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Liver_stage_malaria_parasite.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">Wikimedia Commons<\/a>]<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>","protected":false},"excerpt":{"rendered":"<p>CDK5 regulates atypical cell division in gametogony and is essential for DNA replication, and researchers assess whether two experimental vaccines can be combined to create a multistage vaccine against malaria.<\/p>\n","protected":false},"author":1,"featured_media":16556,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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