{"id":16573,"date":"2020-07-17T06:00:12","date_gmt":"2020-07-17T05:00:12","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16573"},"modified":"2020-07-15T20:46:58","modified_gmt":"2020-07-15T19:46:58","slug":"plasmodium-mimics-nk-inhibitor-to-evade-immune-response","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/plasmodium-mimics-nk-inhibitor-to-evade-immune-response\/","title":{"rendered":"Plasmodium Mimics NK-Inhibitor to Evade Immune Response"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5><p>Researchers find that the malaria parasite mimics a natural molecule that inhibits the release of NK cells, and the effect of insecticide resistance on the reproductive potential of <em>Anopheles coluzzii<\/em> mosquitoes has been revealed.<\/p><!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16573-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-6-15\/90438203-44100-2-f021e60fb5aca.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-6-15\/90438203-44100-2-f021e60fb5aca.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-6-15\/90438203-44100-2-f021e60fb5aca.m4a<\/a><\/audio><p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p><hr \/><h5><strong>Transcript:<\/strong><\/h5><p>The onset of malaria symptoms caused by the rapid replication of <em>Plasmodium<\/em> parasites elicits an innate and adaptive immune response in the human. To evade this response by the immune system, researchers have found that the <em>Plasmodium falciparum<\/em> parasite encodes a protein called RIFIN which mimics a natural molecule called MHC Class I, itself responsible for inhibiting the release of \u2018natural killer\u2019 NK cells. In humans, RIFIN binds to LILRB1, a red blood cell receptor. In doing so, it disrupts the complex and blocks the activation of NK cells.<\/p><p>The effect of insecticide resistance on the reproductive potential of <em>Anopheles coluzzii<\/em> mosquitoes has been revealed. The number of hatched eggs, larvae, pupae and adults were significantly higher in the DDT-resistant compared to the susceptible substrain. Furthermore, 85% of the resistant females were fertilised compared to just 66% of the susceptible females.<\/p><h5><strong>Sources:<\/strong><\/h5><p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1038\/s41586-020-2530-3\" target=\"_blank\" rel=\"noopener noreferrer\">Structural Basis for RIFIN-Mediated Activation of LILRB1 in Malaria<\/a><\/p><p><a href=\"http:\/\/www.jvbd.org\/article.asp?issn=0972-9062;year=2019;volume=56;issue=3;spage=207;epage=211;aulast=Sy;type=0\" target=\"_blank\" rel=\"noopener noreferrer\">Effects of Insecticide Resistance on the Reproductive Potential of Two Sub-Strains of the Malaria Vector <em>Anopheles Coluzzii<\/em><\/a><\/p><p><!-- \/wp:paragraph --><\/p><hr \/><p><strong>Image Credits:\u00a0<\/strong><em>Plasmodium falciparum\u00a0<\/em>schizont [<a href=\"https:\/\/biorender.com\/icon\/species\/other-organisms\/p-falciparum-3-schizont-1\/\" target=\"_blank\" rel=\"noopener noreferrer\">BioRender<\/a>]<!-- wp:paragraph --><\/p><p><strong>Scientific Advisor:<\/strong> Elena G\u00f3mez-D\u00edaz, Institute of Parasitology and Biomedicine, Spain<\/p>","protected":false},"excerpt":{"rendered":"<p>Researchers find that the malaria parasite mimics a natural molecule that inhibits the release of NK cells, and the effect of insecticide resistance on the reproductive potential of Anopheles coluzzii mosquitoes has been revealed.<\/p>\n","protected":false},"author":1,"featured_media":16574,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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