{"id":16735,"date":"2020-08-14T06:00:29","date_gmt":"2020-08-14T05:00:29","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16735"},"modified":"2020-08-07T08:14:20","modified_gmt":"2020-08-07T07:14:20","slug":"peptide-based-pd1-antagonist-stimulates-t-cell-responses","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","title":{"rendered":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses"},"content":{"rendered":"
The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\n

A peptide derived from Bacillus<\/em> bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.<\/p>\n\n

Malaria Minute on iTunes<\/a> and Spotify<\/a><\/p>\n


\n
Transcript:<\/strong><\/h5>\n

The malaria parasite utilises PD1, a protein that suppresses immune responses, to ensure its survival; blocking PD1 induction is, therefore, critical to stop escalation of infection. Researchers have investigated whether LD01, a peptide derived from Bacillus<\/em> bacteria, can prevent such escalation. When combined with a preventative malaria vaccine, LD01 stimulates the production of antigen-specific CD8 T cells. When used therapeutically, the use of the peptide resulted in mouse survival that was associated with fewer suppressive T cells.<\/p>\n

Researchers have explored the use of satellite imagery and big data to assess the suitability of malaria vectors in different geographies. Built on the Google Earth Engine, the tool considers a range of environmental factors that drive vector prevalence. The researchers found that nearly 21% of Malawi is suitable for breeding based on land characteristics alone.<\/p>\n

Sources:<\/strong><\/h5>\n

A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model<\/a><\/p>\n

Leveraging Big Data for Public Health: Mapping Malaria Vector Suitability in Malawi With Google Earth Engine\u00a0<\/a><\/p>\n

<\/p>\n


\n

Image Credits: <\/strong> CDC\/ Dr. Mae Melvin [20373<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"

A peptide derived from Bacillus bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.<\/p>\n","protected":false},"author":1,"featured_media":16738,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"\nPeptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Peptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog\" \/>\n<meta property=\"og:description\" content=\"A peptide derived from Bacillus bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\" \/>\n<meta property=\"og:site_name\" content=\"The Fight Malaria Blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-14T05:00:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-07T07:14:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/08\/Peptide-Based-PD1-Antagonist-Stimulates-T-Cell-Responses.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Thomas Locke\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Thomas Locke\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\"},\"author\":{\"name\":\"Thomas Locke\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a\"},\"headline\":\"Peptide-Based PD1 Antagonist Stimulates T Cell Responses\",\"datePublished\":\"2020-08-14T05:00:29+00:00\",\"dateModified\":\"2020-08-07T07:14:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\"},\"wordCount\":251,\"publisher\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\"},\"articleSection\":[\"Malaria Minute\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\",\"url\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\",\"name\":\"Peptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog\",\"isPartOf\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#website\"},\"datePublished\":\"2020-08-14T05:00:29+00:00\",\"dateModified\":\"2020-08-07T07:14:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/fight-malaria-blog.local\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Peptide-Based PD1 Antagonist Stimulates T Cell Responses\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#website\",\"url\":\"https:\/\/fight-malaria-blog.local\/\",\"name\":\"The Fight Malaria Blog\",\"description\":\"Malaria News, Views and Interviews.\",\"publisher\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fight-malaria-blog.local\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#organization\",\"name\":\"Fight Malaria\",\"url\":\"https:\/\/fight-malaria-blog.local\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg\",\"contentUrl\":\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg\",\"caption\":\"Fight Malaria\"},\"image\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a\",\"name\":\"Thomas Locke\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g\",\"caption\":\"Thomas Locke\"},\"url\":\"https:\/\/fight-malaria-blog.local\/author\/fightmalaria\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","og_locale":"en_GB","og_type":"article","og_title":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog","og_description":"A peptide derived from Bacillus bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.","og_url":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","og_site_name":"The Fight Malaria Blog","article_published_time":"2020-08-14T05:00:29+00:00","article_modified_time":"2020-08-07T07:14:20+00:00","og_image":[{"width":800,"height":500,"url":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/08\/Peptide-Based-PD1-Antagonist-Stimulates-T-Cell-Responses.png","type":"image\/png"}],"author":"Thomas Locke","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Thomas Locke","Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#article","isPartOf":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/"},"author":{"name":"Thomas Locke","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a"},"headline":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses","datePublished":"2020-08-14T05:00:29+00:00","dateModified":"2020-08-07T07:14:20+00:00","mainEntityOfPage":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/"},"wordCount":251,"publisher":{"@id":"https:\/\/fight-malaria-blog.local\/#organization"},"articleSection":["Malaria Minute"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","url":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","name":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses - The Fight Malaria Blog","isPartOf":{"@id":"https:\/\/fight-malaria-blog.local\/#website"},"datePublished":"2020-08-14T05:00:29+00:00","dateModified":"2020-08-07T07:14:20+00:00","breadcrumb":{"@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/fight-malaria-blog.local\/"},{"@type":"ListItem","position":2,"name":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses"}]},{"@type":"WebSite","@id":"https:\/\/fight-malaria-blog.local\/#website","url":"https:\/\/fight-malaria-blog.local\/","name":"The Fight Malaria Blog","description":"Malaria News, Views and Interviews.","publisher":{"@id":"https:\/\/fight-malaria-blog.local\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fight-malaria-blog.local\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/fight-malaria-blog.local\/#organization","name":"Fight Malaria","url":"https:\/\/fight-malaria-blog.local\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/","url":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg","contentUrl":"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/07\/blog_logo-20200728-212450.svg","caption":"Fight Malaria"},"image":{"@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a","name":"Thomas Locke","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4e07b1fc2fb741436038290480c02087?s=96&d=mm&r=g","caption":"Thomas Locke"},"url":"https:\/\/fight-malaria-blog.local\/author\/fightmalaria\/"}]}},"_links":{"self":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts\/16735"}],"collection":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/comments?post=16735"}],"version-history":[{"count":0,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/posts\/16735\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/media\/16738"}],"wp:attachment":[{"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/media?parent=16735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/categories?post=16735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fight-malaria-blog.local\/wp-json\/wp\/v2\/tags?post=16735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}