{"id":16735,"date":"2020-08-14T06:00:29","date_gmt":"2020-08-14T05:00:29","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16735"},"modified":"2020-08-07T08:14:20","modified_gmt":"2020-08-07T07:14:20","slug":"peptide-based-pd1-antagonist-stimulates-t-cell-responses","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/peptide-based-pd1-antagonist-stimulates-t-cell-responses\/","title":{"rendered":"Peptide-Based PD1 Antagonist Stimulates T Cell Responses"},"content":{"rendered":"
The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\n

A peptide derived from Bacillus<\/em> bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.<\/p>\n\n

Malaria Minute on iTunes<\/a> and Spotify<\/a><\/p>\n

\n
Transcript:<\/strong><\/h5>\n

The malaria parasite utilises PD1, a protein that suppresses immune responses, to ensure its survival; blocking PD1 induction is, therefore, critical to stop escalation of infection. Researchers have investigated whether LD01, a peptide derived from Bacillus<\/em> bacteria, can prevent such escalation. When combined with a preventative malaria vaccine, LD01 stimulates the production of antigen-specific CD8 T cells. When used therapeutically, the use of the peptide resulted in mouse survival that was associated with fewer suppressive T cells.<\/p>\n

Researchers have explored the use of satellite imagery and big data to assess the suitability of malaria vectors in different geographies. Built on the Google Earth Engine, the tool considers a range of environmental factors that drive vector prevalence. The researchers found that nearly 21% of Malawi is suitable for breeding based on land characteristics alone.<\/p>\n

Sources:<\/strong><\/h5>\n

A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model<\/a><\/p>\n

Leveraging Big Data for Public Health: Mapping Malaria Vector Suitability in Malawi With Google Earth Engine\u00a0<\/a><\/p>\n

<\/p>\n

\n

Image Credits: <\/strong> CDC\/ Dr. Mae Melvin [20373<\/a>]<\/p>\n","protected":false},"excerpt":{"rendered":"

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