Researchers produce a \u2018cell atlas\u2019 of the mosquito immune system, and new hydrological prediction models identify a more complex pattern of malaria suitability.<\/p>\n
Malaria Minute on iTunes<\/a> and Spotify<\/a><\/p>
Researchers have produced a \u2018cell atlas\u2019 of the mosquito immune system using single-cell sequencing. This more granular understanding of how the mosquito fights infection at the cellular level is key to developing new therapies against malaria. One potential approach involves \u2018immune priming\u2019; stimulating immune cells to develop adaptive immunity and protection for future infection. The researchers in this study identified that a particular cell, the megacyte, is involved in this process.<\/p>
Malaria transmission is dependent on both air temperature and the availability of stagnant water, and both are dependent on climate change. By using models that consider water movement and usage – not just the amount of water falling from the sky – researchers have identified a more complex pattern of malaria suitability. This new type of hydrological model demonstrates different transmission patterns depending on the local geography.<\/p>
Mosquito Cellular Immunity at Single-Cell Resolution<\/a><\/p>
Image Credits:\u00a0<\/strong>CDC\/ James Gathany [18754<\/a>]<\/p>