{"id":16768,"date":"2020-09-18T06:00:51","date_gmt":"2020-09-18T05:00:51","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16768"},"modified":"2020-09-16T21:25:36","modified_gmt":"2020-09-16T20:25:36","slug":"multidose-priming-and-delayed-boosting-improves-pfspz-vaccine-efficacy","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/multidose-priming-and-delayed-boosting-improves-pfspz-vaccine-efficacy\/","title":{"rendered":"Multidose Priming and Delayed Boosting Improves PfSPZ Vaccine Efficacy"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\r\n<p>Multi-dose priming and delayed boosting improves PfSPZ protection against different strains of malaria, and registration opens for this year\u2019s Molecular Parasitology Meeting.<\/p>\r\n<!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16768-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-8-16\/107991315-44100-2-c1e0d21dd4891.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-8-16\/107991315-44100-2-c1e0d21dd4891.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-8-16\/107991315-44100-2-c1e0d21dd4891.m4a<\/a><\/audio>\r\n<p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p>\r\n<hr \/>\r\n<h5><strong>Transcript:<\/strong><\/h5>\r\n<p>PfSPZ, a live-attenuated malaria vaccine, has been shown to offer up to 100% protection against homologous strains of <em>P. falciparum<\/em> (the same strain as in the vaccine). New research focuses on making the vaccine effective against other strains of the disease. It\u2019s been found that 5 doses of the vaccine over 16 weeks can offer 40% protection against heterologous strains of malaria, an effect that increases to 64% with vaccine boosting after 12 weeks. Although logistical and adherence challenges remain from using the vaccine, this new research demonstrates that multi-dose priming, and a delayed booster dose for those not protected after the first controlled infection, significantly improves protection.<\/p>\r\n<p>Registration has opened for this year\u2019s Molecular Parasitology Meeting of the Genetics Society of America. The virtual event will include a symposium on \u2018Black Lives Matter in Parasitology\u2019.<\/p>\r\n<h5><strong>Sources:<\/strong><\/h5>\r\n<p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa1294\" target=\"_blank\" rel=\"noopener noreferrer\">Multidose Priming and Delayed Boosting Improve PfSPZ Vaccine Efficacy against Heterologous P. falciparum Controlled Human Malaria Infection<\/a><\/p>\r\n<p><a href=\"https:\/\/genetics-gsa.org\/parasitology-2020\/\" target=\"_blank\" rel=\"noopener noreferrer\">Molecular Parasitology Meeting XXXI<\/a><\/p>\r\n<p><!-- \/wp:paragraph --><\/p>\r\n<hr \/>\r\n<p><strong>Image Credits:<\/strong> CDC\/ Dr. Mae Melvin [<a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=17696\" target=\"_blank\" rel=\"noopener noreferrer\">17696<\/a>]<\/p>\r\n<p><!-- wp:paragraph --><\/p>\r\n<p><strong>Scientific Advisor:<\/strong> <span>Elena G\u00f3mez-D\u00edaz, Institute of Parasitology and Biomedicine, Spain<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Multi-dose priming and delayed boosting improves PfSPZ protection against different strains of malaria, and registration opens for this year\u2019s Molecular Parasitology Meeting.<\/p>\n","protected":false},"author":1,"featured_media":16769,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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