{"id":16784,"date":"2020-10-09T06:00:14","date_gmt":"2020-10-09T05:00:14","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16784"},"modified":"2020-10-07T23:13:58","modified_gmt":"2020-10-07T22:13:58","slug":"new-insight-into-heat-resistance-of-plasmodium-parasites","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/new-insight-into-heat-resistance-of-plasmodium-parasites\/","title":{"rendered":"New Insight Into Heat Resistance of Plasmodium Parasites"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\r\n<p>Researchers detail the role of PI(3)P in preventing heat-shock-induced cell death and the BK-SE36 adjuvanted malaria vaccine is found to be safe, well-tolerated and protective in clinical trials.<\/p>\r\n<!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16784-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-9-7\/116084824-44100-2-5371b0e8f7be5.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-9-7\/116084824-44100-2-5371b0e8f7be5.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-9-7\/116084824-44100-2-5371b0e8f7be5.m4a<\/a><\/audio>\r\n<p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p>\r\n<hr \/>\r\n<h5><strong>Transcript:<\/strong><\/h5>\r\n<p>Over the course of its lifecycle, <em>Plasmodium falciparum<\/em> malaria parasites are exposed to different environmental pressures, for example, the high temperatures during the fever episode of human blood-stage infection. Researchers have now found that a particular phosphate &#8211; phosphatidylinositol 3-phosphate, or PI(3)P, stabilises the digestive vacuole of the parasite preventing heat-shock-induced cell death. Researchers found that PI(3)P-deficient parasites are not able to cope with the fever\u2019s heat and that a PI3P-binding protein, PfHsp70, is also critical for parasite survival under heat stress.<\/p>\r\n<p>The results are in from a Phase 1a clinical trial of the adjuvanted malaria vaccine, BK-SE36. The trial involved 26 malaria-naive adults and found that the vaccine is safe, well-tolerated and, when given in two doses 21 days apart, offers great protection.<\/p>\r\n<h5><strong>Sources:<\/strong><\/h5>\r\n<p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.7554\/eLife.56773\" target=\"_blank\" rel=\"noopener noreferrer\">Phosphatidylinositol 3-phosphate and Hsp70 Protect <em>Plasmodium falciparum<\/em> From Heat-Induced Cell Death<\/a><\/p>\r\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.vaccine.2020.09.056\" target=\"_blank\" rel=\"noopener noreferrer\">First-in-Human Randomised Trial and Follow-up Study of <em>Plasmodium falciparum<\/em> Blood-Stage Malaria Vaccine BK-SE36 with CpG-ODN(K3)<\/a><\/p>\r\n<p><!-- \/wp:paragraph --><\/p>\r\n<hr \/>\r\n<p><strong>Image Credits:<\/strong> CDC\/ Dr. Mae Melvin [<a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=17368\" target=\"_blank\" rel=\"noopener noreferrer\">17368<\/a>]<\/p>\r\n<p><!-- wp:paragraph --><\/p>\r\n<p><strong>Scientific Advisor: <\/strong><span>Elena G\u00f3mez-D\u00edaz, Institute of Parasitology and Biomedicine, Spain<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Researchers detail the role of PI(3)P in preventing heat-shock induced cell death and the BK-SE36 adjuvanted malaria vaccine is found to be safe, well-tolerated and protective in clinical trials.<\/p>\n","protected":false},"author":1,"featured_media":16785,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - 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