{"id":16829,"date":"2020-11-27T06:00:04","date_gmt":"2020-11-27T06:00:04","guid":{"rendered":"https:\/\/fight-malaria-blog.local\/?p=16829"},"modified":"2020-11-26T07:05:03","modified_gmt":"2020-11-26T07:05:03","slug":"conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei","status":"publish","type":"post","link":"https:\/\/fight-malaria-blog.local\/malaria-minute\/conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei\/","title":{"rendered":"Conserved Antigen Pb22 Plays a Critical Role in Male Gametogenesis in P. Berghei"},"content":{"rendered":"<h5><strong>The Latest Malaria News, in 60 Seconds.<\/strong><\/h5>\r\n<p>Pb22, a protein expressed by Plasmodium berghei, may play an important role in the transmission of malaria, and review on the use of tafenoquine finds that the drug is well-tolerated and effective.<\/p>\r\n<!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-16829-1\" autoplay=\"1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-10-26\/132152443-44100-2-c3c122513c848.m4a?_=1\" \/><a href=\"https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-10-26\/132152443-44100-2-c3c122513c848.m4a\">https:\/\/d3ctxlq1ktw2nl.cloudfront.net\/staging\/2020-10-26\/132152443-44100-2-c3c122513c848.m4a<\/a><\/audio>\r\n<p>Malaria Minute on <a href=\"https:\/\/itunes.apple.com\/gb\/podcast\/malaria-minute\/id1355091623\" target=\"_blank\" rel=\"noreferrer noopener\">iTunes<\/a> and <a href=\"https:\/\/open.spotify.com\/show\/5ucD00RxBqAaf29Km7lFOI\" target=\"_blank\" rel=\"noreferrer noopener\">Spotify<\/a><\/p>\r\n<hr \/>\r\n<h5><strong>Transcript:<\/strong><\/h5>\r\n<p>Pb22, a protein expressed by the mouse malaria parasite <em>Plasmodium berghei<\/em>, may play an important role in the transmission of malaria. In parasites without the protein, less exflagellation was recorded <em>in vitro<\/em>, and the ability of the parasite to form ookinetes and oocysts &#8211; critical stages of its life cycle in the mosquito &#8211; was prevented. And antibodies from mice immunised with the protein almost completely blocked transmission to mosquitoes. The Pb22 homologues in human malaria parasites could, therefore, be an important target for transmission-blocking therapies and warrant investigation.<\/p>\r\n<p>A review on the use of tafenoquine in preventing malaria has found that the drug is well-tolerated and effective for both <em>P. falciparum<\/em> and <em>P. vivax<\/em> malaria, with adverse events comparable to other drugs. Patients must be tested for G6PD-deficiency beforehand, however, as the drug can cause anaemia for those with the condition.<\/p>\r\n<h5><strong>Sources:<\/strong><\/h5>\r\n<p class=\"highwire-cite-title\"><a href=\"https:\/\/doi.org\/10.1111\/cmi.13294\" target=\"_blank\" rel=\"noopener noreferrer\">A Conserved Malaria Parasite Antigen Pb22 Plays a Critical Role in Male Gametogenesis in <em>Plasmodium Berghei<\/em><\/a><\/p>\r\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.tmaid.2020.101908\" target=\"_blank\" rel=\"noopener noreferrer\">Efficacy and Safety of Tafenoquine for Malaria Chemoprophylaxis (1998-2020): A Systematic Review and Meta-Analysis<\/a><\/p>\r\n<p><!-- \/wp:paragraph --><\/p>\r\n<hr \/>\r\n<p><strong>Image Credits:<\/strong> <span>CDC\/ Dr. Mae Melvin [<\/span><a href=\"https:\/\/phil.cdc.gov\/Details.aspx?pid=18761\" target=\"_blank\" rel=\"noopener noreferrer\">18761<\/a><span>]<\/span><\/p>\r\n<p><!-- wp:paragraph --><\/p>\r\n<p><strong>Scientific Advisor:<\/strong> Katharine Collins, Radboud University Medical Centre<\/p>","protected":false},"excerpt":{"rendered":"<p>Pb22, a protein expressed by Plasmodium berghei, may play an important role in the transmission of malaria, and review on the use of tafenoquine finds that the drug is well-tolerated and effective.<\/p>\n","protected":false},"author":1,"featured_media":16830,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[9],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Conserved Antigen Pb22 Plays a Critical Role in Male Gametogenesis in P. Berghei - The Fight Malaria Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Conserved Antigen Pb22 Plays a Critical Role in Male Gametogenesis in P. Berghei - The Fight Malaria Blog\" \/>\n<meta property=\"og:description\" content=\"Pb22, a protein expressed by Plasmodium berghei, may play an important role in the transmission of malaria, and review on the use of tafenoquine finds that the drug is well-tolerated and effective.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fight-malaria-blog.local\/malaria-minute\/conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei\/\" \/>\n<meta property=\"og:site_name\" content=\"The Fight Malaria Blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-27T06:00:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-26T07:05:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fight-malaria-blog.local\/wp-content\/uploads\/2020\/11\/Conserved-Antigen-Pb22-Plays-a-Critical-Role-in-Male-Gametogenesis-in-P.-Berghei.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Thomas Locke\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Thomas Locke\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/fight-malaria-blog.local\/malaria-minute\/conserved-antigen-pb22-plays-a-critical-role-in-male-gametogenesis-in-p-berghei\/\"},\"author\":{\"name\":\"Thomas Locke\",\"@id\":\"https:\/\/fight-malaria-blog.local\/#\/schema\/person\/866d37307e013f5a16202221b93ef75a\"},\"headline\":\"Conserved Antigen Pb22 Plays a Critical Role in Male Gametogenesis in P. 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