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Researchers from the Pasteur Institute discover molecules that can kill the malaria parasite and researchers from LSTM identify a resistance mechanism for insecticides used on bed nets.
Researchers from the Pasteur Institute in France have identified molecules that can kill the malaria parasite.
To transmit malaria, the parasite requires two hosts: humans and female Anopheles mosquitoes. As it’s transmitted between them, it adapts to its environment through a process called DNA methylation.
The addition of molecules that inhibit this process has proven successful in killing the malaria parasites. In vitro, the molecules killed artemisinin-resistant P. falciparum parasites, some of which within the space of six hours.
And researchers from the Liverpool School of Tropical Medicine have identified a resistance mechanism for insecticides used on bed nets.
A particular protein, called SAP2, was found to be higher in populations of insecticide-resistant parasites. When they partially silenced the gene, their susceptibility to pyrethroids was restored.
The researchers screened both gambiae and coluzzii.
Image Credits: Pasteur Institute
Scientific Advisor: Katharine Collins, Radboud University Medical Centre