Peptide-Based PD1 Antagonist Stimulates T Cell Responses

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A peptide derived from Bacillus bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.

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Transcript:

The malaria parasite utilises PD1, a protein that suppresses immune responses, to ensure its survival; blocking PD1 induction is, therefore, critical to stop escalation of infection. Researchers have investigated whether LD01, a peptide derived from Bacillus bacteria, can prevent such escalation. When combined with a preventative malaria vaccine, LD01 stimulates the production of antigen-specific CD8 T cells. When used therapeutically, the use of the peptide resulted in mouse survival that was associated with fewer suppressive T cells.

Researchers have explored the use of satellite imagery and big data to assess the suitability of malaria vectors in different geographies. Built on the Google Earth Engine, the tool considers a range of environmental factors that drive vector prevalence. The researchers found that nearly 21% of Malawi is suitable for breeding based on land characteristics alone.

Sources:

A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model

Leveraging Big Data for Public Health: Mapping Malaria Vector Suitability in Malawi With Google Earth Engine 

Image Credits: CDC/ Dr. Mae Melvin [20373]